•Randomized, double-blind,
placebo-controlled study of
–248
patients
•Mean IBDQ compared with placebo at Week
6
–Natalizumab
3 mg/kg at Week 0 (p=0.008)
–Natalizumab
3 mg/kg at Week 0 and Week 4 (p<0.001)
–Natalizumab
6 mg/kg at Week 0 and Week 4 (p<0.001)
•Patients receiving 2 infusions of
natalizumab
–Statistically
greater improvement in all 4 IBDQ dimensions compared with
placebo (p<0.05)